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KMID : 0374019880110040283
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Ewha Medical Journal
1988 Volume.11 No. 4 p.283 ~ p.297
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The Protective Effect of Mannitol and Mehtylprednisolone in the Acute Focal Cerebral Ischemia in Cats
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Abstract
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It is the purpose of the this experimental study to investigate the protective effect of pretreatment of mannitol and methylprednisolone(MP) on the changes of the high-energy metabolites (nucleotides : derivatives of adenosine, guanosine, uracil and cystosine) and adenylate energy charge in the brain tissue of the cats. The experimental animals were divied into three groups. Group I was the sham control groups that the postorbital approach was performed but no occlusion of MCA. Group II was the recirculation group that of 2-hour recirculation after the occlusion of the middle cerebral artery(MCA) via the postorbital approach. Group Ill was that of pretreatment of the combination of mannitol(29mglkg) and MP(3mg/kg) at 30 minutes before occlusion of the MCA and then every one and a half hours during the 5-hour occlusion and 2-hour recirculation.
The experimental results are as follows.
1) Adenosine derivatives : In group Ill ATP was significantly increased to 622.9%, ADP significantly increased to 154.81%, AMP reduced 68.05% and total adenosine nucleotides increased to 103.63% of the values of group III:
2) Adenylate energy charge(E.C.) : In group Ill E.C. was recovered to 82.66% and increased to 206.66% of the values of group H.
3) Guanosine derivatives : In group Ill GTP was bignificantly increased to 554.03GDP increased to 96.61% and GMP reduced to 62.71% of the values of the group II .
4) Uracil derivatives In group Ill UTP and UDP"was significantly increased to 470.37%, and 300.64% `respectively and UMP was reduced to 91.7% of values of group lI .
5) Cystosine derivatives In group III ´CTP was increased to 133.33%, CDP reduced to 90.0% and CMP increased to 119.03% of values of group II.
These above results suggested that pretreatment of mannitol and MP have a protective effect
on the acute focal cerebral ischemia when given prior to the onset of the ischemia by the stabiliza-
tion of the energy regulation and maintenance of a higher level of adenylate E.C.
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